Regular paracetamol in severe dengue: a lethal combination?

Gan, C.S.; Chong, S.Y.; Lum, L.C.S.; Lee, W.S. (2013) Regular paracetamol in severe dengue: a lethal combination? Singapore Medical Journal, 54 (2). E35-E37. ISSN 0037-5675

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    Abstract

    An eight-month-old female infant with severe dengue disease, who was repeatedly given therapeutic paracetamol for severe dengue, developed fulminant liver failure with encephalopathy, gastrointestinal haemorrhage and severe coagulopathy. She responded to supportive measures and N-acetylcysteine infusion. This case highlights the potential danger of administering repeated therapeutic doses of paracetamol in childhood severe dengue disease with hepatitis.

    Item Type: Article
    Creators:
    1. Gan, C.S.
    2. Chong, S.Y.
    3. Lum, L.C.S.
    4. Lee, W.S.(Department of Paediatrics, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA)
    Journal or Publication Title: Singapore Medical Journal
    Uncontrolled Keywords: Hepatitis; paracetamol; severe dengue; acute liver-failure; hepatotoxicity; infection; hepatitis; children
    Subjects: R Medicine
    R Medicine > RJ Pediatrics
    Divisions: Faculty of Medicine
    Depositing User: Ms Haslinda Lahuddin
    Date Deposited: 13 Jul 2014 14:35
    Last Modified: 13 Jul 2014 14:35
    URI: http://eprints.um.edu.my/id/eprint/10877

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